Dr. Scales conducts epidemiological and health services research examining system-level factors that influence the outcomes of critically ill patients. He also conducts large individual patient and cluster randomized controlled trials (RCTs) of interventions to improve outcomes for critically ill patients. These include the PITSTOP RCT investigating a prehospital sepsis intervention (NCT03068741); the PROTEST RCT (NCT03559114) evaluating early versus late anticoagulant thromboprophylaxis for patients with traumatic brain injury; and the HONOUR RCT (NCT05078034) comparing high flow nasal oxygen with or without helmet non-invasive ventilation for patients with acute hypoxemic respiratory failure.
Dr. Scales is a Professor of Medicine at University of Toronto and the Chief of Critical Care at Sunnybrook Health Sciences Centre in Toronto.
The Canadian COVID-19 Prospective Cohort Study (CANCOV) is a platform observational study that provides a comprehensive evaluation of early to 2-year outcomes in patients with COVID-19 and their family caregivers.
Long Term Cardiovascular Outcomes After Sepsis