Advanced Topics In Measurement


HAD5302H Measurement in Clinical Research
HAD5316H – Biostatistics II: Advanced Techniques in Applied Regression Methods


This course will cover topics in measurement theory and application beyond the basic principles covered in HAD5302H, Measurement in Clinical Research. Specifically, it will cover the theory, application and interpretation of more advanced approaches and statistical techniques such as confirmatory factor analysis, structural equation modeling, item response theory approaches, measurement error, minimally clinically important differences, response shift, conjoint analysis, discrete choice experiments and the mapping of measures to utility functions as they apply to measurement theory. The course mainly will be structured such that the first week will provide the theory and with the subsequent week(s) providing discussion of study design issues and interpretation of data output. Students will not be analyzing data.


The intent of the course is that students will understand the theory of the approach such that they can consider when the application is appropriate to use and critique work published work from a methodological and interpretive perspective.



Students will be responsible for writing a structured synopsis/review of maximum two pages on four topics, each worth 25% of the final grade. The review topics include: 1) confirmatory factor analysis/SEM; 2) measurement error and minimally clinically important differences; 3) item response theory approaches or conjoint analysis; and, 4) response shift. The articles to be reviewed will be provided to the student two weeks prior to the review due date.